ANTITUMOR DRUGS: A NEW APPROACH
by Acad. Georgi GEORGIEV and Alexandr SOBOLEV, Dr. Sc. (Biol.), Institute of Gene Biology, Russian Academy of Sciences The main problem of drug treatment of cancer using chemo-, radio, photodynamic therapy or other methods is in grave side effects from which the patients suffer. All types of cancer cell exposure unfortunately involve normal, intensely dividing cells with the same characteristics. The task of scientists is to increase the selectivity of drug action. This can be attained by drug delivery to transformed cells by means of multimodular carriers. THERAPEUTIC EFFECT OF LIGHT Therapeutic and diagnostic methods based on recent progress in photochemistry, photobiology, nuclear physics and chemistry have been ever more often used in oncology in these two last decades. One promising approach is offered by photodynamic therapy (PDT), when a photosensitizer drug accumulated in the tumor destroys it by absorbing the irradiating light. The photosensitizer proper is nontoxic for the malignant tumor, but the so-called active oxygen forms (AOF), appearing during its illumination in the presence of O2, are destructive: these are singlet oxygen (1O2), hydroxyl radical (•OH), and others; many molecules in the cell (proteins, lipids, nucleic acids) and supramolecular structures formed by them serve as targets for AOF. An intricate succession of photochemical and photobiological processes leads to irreversible damage to cancer tumor cells and/or vessels. As it often happens, the idea of using light-activated chemical compounds for the treatment of various diseases is not new. Vitiligo (skin disease) was treated in ancient Egypt using plants containing psoralenes* and sunlight. Recently (in 1903) a Danish scientist Niels R. * Psoralenes are natural photosensitizers contained in extracts from seeds of umbellate plants (Ammi majus L.) and legumes (Psoralea corylifolia L.) and their synthetic analogs. - Auth. стр. 40 F ... Read more
____________________

Эта публикация была размещена на Либмонстре в другой стране и показалась интересной редакторам.

Полная версия: http://libmonster.com/m/articles/view/ANTITUMOR-DRUGS-A-NEW-APPROACH
Moldova Online · 1623 days ago 0 218
Professional Authors' Comments:
Order by: 
Per page: 
 
  • There are no comments yet
Guest comments




Who Like this
Likes · Dislikes
 
Empty
Actions
Rate
0 votes
Publisher
Moldova Online
Кишинев, Moldova
20.10.2018 (1623 days ago)
Link
Permanent link to this publication:

http://library.md/blogs/entry/ANTITUMOR-DRUGS-A-NEW-APPROACH


© library.md
 

Libmonster, International Network:

Actual publications:

Libmonster Partners

Actual publications:

Latest ARTICLES:

Latest BOOKS:

Actual publications:

LIBRARY.MD is a Moldavian open digital library, repository of author's heritage and archive

Register & start to create your original collection of articles, books, research, biographies, photographs, files. It's convenient and free. Click here to register as an author. Share with the world your works!
ANTITUMOR DRUGS: A NEW APPROACH
 

Contacts
Watch out for new publications: News only: Chat for Authors:

About · News · For Advertisers · Donate to Libmonster

Library of Moldova ® All rights reserved.
2016-2023, LIBRARY.MD is a part of Libmonster, international library network (open map)
Keeping the heritage of Moldova


LIBMONSTER NETWORK ONE WORLD - ONE LIBRARY

US-Great Britain Sweden Serbia
Russia Belarus Ukraine Kazakhstan Moldova Tajikistan Estonia Russia-2 Belarus-2

Create and store your author's collection at Libmonster: articles, books, studies. Libmonster will spread your heritage all over the world (through a network of branches, partner libraries, search engines, social networks). You will be able to share a link to your profile with colleagues, students, readers and other interested parties, in order to acquaint them with your copyright heritage. After registration at your disposal - more than 100 tools for creating your own author's collection. It is free: it was, it is and always will be.

Download app for smartphones